Monday, June 10th

Registration and Light Refreshments
Session #1: Opening Session
Aviv Regev (Broad Institute)
*Opening remarks
Hon Nir Barkat, Mayor of Jerusalem
Menahem Ben-Sasson The President of the Hebrew University
Benjamin Geiger Chairman, ISF's Academic Board
*Opening Keynote
Eric Lander (Broad Institute)
*Multi-scale chromosomal domains and their possible regulatory implications
Amos Tanay (Weizmann Institute)
Coffee Break
Session #2: Chromatin
*Maintaining the differentiated state; lessons from flies
Amir Orian (Technion)
* A library of endogenously tagged fluorescent proteins in embryonic stem cells reveals a linker histone chaperone involved in pluripotency and differentiation
Eran Meshorer (Hebrew University)
* Establishment of chromatin landscape and transcriptional program in early Drosophila development
Tommy Kaplan (Hebrew University)
* Does intragenic DNA methylation determine differential exon expression?
Yael Mandel-Gutfreund (Technion)
* Mapping chromatin in single cells with microfluidics
Assaf Rotem/Oren Ram (Harvard/Broad Institute)
* Tweaking the chromatin to direct & deterministic cell reprogramming
Noa Novershtern (Weizmann Institute)
Session #3: Single Cells/Technology
* Nano-bio Interfaces for Cell-Circuit Studies
Hongkun Park (Harvard)
* Dissecting the embryo with single cell RNA-Seq
Itai Yanai (Technion)
* Evidence for deterministic inheritance of mammalian cell-cycle duration
Nathalie Questembert-Balaban (Hebrew University)
* Single-cell genomics for pathway discovery in microbial \'dark matter
Paul Blainey (Broad Institute)
* Somatic cells are predisposed to their response during iPSC reprogramming
Iftach Nachman (Tel Aviv University)
* Multi Disciplinary Technology Development for Genomics
Robert Nicol (Broad Institute)
Coffee Break
Session #4: Model Organisms
* Clk RNA turnover denoises circadian transcription in time and space
Sebastian Kadener (Hebrew University)
* Principles of antisense RNA regulation in bacteria
Rotem Sorek (Weizmann Institute)
* Bacteria as suitable models for studying RNA localization and localized translation
Orna Amster-Choder (Hebrew University)
* What's in a proteome? Lessons from quantitative genome-wide protein abundance studies
Ron Milo (Weizmann Institute)
Keynote: Optimizing resource allocation in the budding yeast: a novel stress-response strategy?
Naama Barkai (Weizmann Institute)
End of day remarks
Opening Reception + Poster session

Tuesday, June 11th

Registration and Light Refreshments
Session #1: Immune Cells
*Keynote: DNA Methylation Dynamics in Stem Cells and Development
Alexander Meissner (Broad Institute)
* DNA Degradation, Sensing and Autoimmunity
Nir Hacohen (Broad Institute)
* Cell fate decisions in the hematopoietic system
Yehudit Bergman (Hebrew University)
* Cellular and viral miRNAs controlling NK cell activity
Ofer Mandelboim (Hebrew University)
* Reduced cytokine responses under chronic inflammatory condition
Shai Shen-Orr (Technion)
* Genome organization dynamics in T lymphocyte differentiation - gene regulation in 3D
Ofir Hakim (Bar Ilan University)
Coffee Break
Session #2:Disease
* Gender disparity in liver cancer - the role of IL6
Eithan Galun (Hebrew University)
* Defining and targeting transcriptional circuits in leukemia stem cells
Benjamin Ebert (Harvard)
* Eradication of tumors by recruiting the immune system utilizing targeted dsRNA
Alexander Levitzki (Hebrew University)
* Unraveling the Metabolic Changes Induced by HCV Infection
Yaakov Nahmias (Hebrew University)
* Beta cell failure in type 2 diabetes
Yuval Dor (Hebrew University)
* Decoding genetic variation in innate immunity
Irit Gat-Viks (Tel-Aviv University)
City Tour (city of David, Kotel Tunnels)
Reception and Dinner Mamila Hotel
* Broad Institute-Israel Partnership for Cell Circuit Research Award Ceremony
Banquet Speakers:
* The Drama of the Human Brain Project
Idan Segev (Hebrew University)
* New worlds in our galaxy - Are we alone?
Re'em Sari (Hebrew University)

Wednesday, June 12th

Registration and Light Refreshments
Session #1: Immune Cells
* Keynote: Programming of DNA methylation during development
Howard Cedar (Hebrew University)
* Principles of chromatin and gene expression dynamics in the immune system during development and response
Ido Amit (Weizmann Institute)
* Single cell transcriptomics : exploring cellular heterogeneity in immune response
Rahul Satija (Broad Institute)
* Transcriptional regulation of proinflamamtory Th17 cells
Vijay Kuchroo (Harvard)
* Randomly made yet ordered: new perspectives on T cell receptor repertoires revealed by high-throughput sequencing
Nir Friedman (Weizmann Institute)
Coffee Break
Session # 2: Disease
* Single cell analysis applied to infection with bacteria
Deborah Hung (Broad Institute)
* Disruption of Chromatin Regulation in Autism
Sagiv Shifman (Hebrew University)
* Control of breast cancer differentiation state
Ittai Ben-Porath (Hebrew University)
* Inflammatory Micro-niches nursing liver cancer progenitor cells
Eli Pikarsky (Hebrew University)
* Transcriptional Networks Provide a Window Into the Neural Circuitry of Addiction
Ami Citri (Hebrew University)
* Mutational and Functional Analysis of Melanoma-Filling in the Gap
Yardena Samuels (Weizmann Institute)
Session #3: Disease
* Clonal Evolution in CLL
Catherine Wu (Broad)
* Decoding the Tissue-Specificity of Hereditary Diseases by using Network Biology
Esti Yeger-Lotem (Ben Gurion University)
* Reconstructing and reprogramming the developmental hierarchy of glioblastoma
Mario Suva (Broad Institute)
* Single-cell gene expression in tissues, tumors, and cell lines
Tomer Kalisky (Bar Ilan University)
* Single Molecule Study of Translation Initiation Factor 4A
Amit Meller (Technion)
Coffee Break
Session #4: Non-coding RNA
* Competition between RNAi and RNA Editing pathways has a role in transcriptome regulation
Ayelet Lamm (Technion)
* Regulating gene expression with RNA
Shoshy Altuvia (Hebrew University)
* The landscape of Adenosine-to-inosine RNA editing in human
Erez Levanon (Bar Ilan University)
* Transgenerational Inheritance of small RNAs in C.elegans
Oded Rechavi (Tel Aviv University)
* MicroRNAs mediate developmental toxicity
Noam Shomron (Tel Aviv University)
Keynote: Circular RNAs
Nikolaus Rajewsky (MDC Berlin)
End of symposium remarks